Infertility article review and discussion Title of article: Relationship of follicle numbers and estradiol levels to multiple implantation in 3, intrauterine insemination cycles Authors : Richard P. Background on ovarian stimulation for infertility and multiple birth risks: Multiple pregnancy — particularly triplets and higher — is a very significant problem in the world of infertility treatment. So how aggressive should we be we be with the ovarian stimulating drugs?
How much do pregnancy rates differ according to how many follicles there are? What about effects on multiple pregnancy rates? Should we try to stimulate so that there are 2 eggs per month instead of the 1 that matures in a natural menstrual cycle?
Or, should we try to get 3, or more than 3? Does the age of the woman matter much? Does the type of stimulating drug matter? Does the peak estrogen hormone level before ovulation matter? How this study was done: The stated objective of the study: To determine the relationship of follicle numbers and estradiol E2 levels to multiple implantations in human menopausal gonadotropin HMG injectable gonadotropins and clomiphene citrate Clomid, Serophene cycles.
Design of the study : Fifteen-year prospective study. Clomiphene citrate cycles - Clomid Of clomiphene pregnancies, 14 8. No triplet implantations occurred after age 33 in clomiphene cycles. In HMG cycles, the number of follicles decreased with age, from 7.
The implantation rates per follicle were identical for all three stimulation regimens and decreased sharply after age No triplet implantations occurred in the clomiphene cycles in which E2 was measured. Prev Previous. Next Next. Share on facebook. Share on twitter. Share on linkedin. Related Articles. Varicoceles in Men and Infertility When should surgery be done?
Numerous sperm — at high magnification on a counting chamber. I am on my 7th IUI cycle a miscarriage on the 4th attempt. This month I have 7 follicles mature and ready to go. I am 36 years old. We would gladly welcome twins or even triplets.
I cannot give you a statistical risk as that number does not exist, but I would expect the risk to be high. Keep in mind that even twins are a high risk pregnancy and should not be taken lightly! I had an IVF patient this week who was pregnant with twins that just lost both at 23 weeks due to premature labor and delivery. It is heartbreaking. That is why we try not to have twins and definitely , try not to have triplets.
I will allow up to 5 mature follicles at 36 years old, but no more than that. Pasqualotto, E. Sassoon, D. Seoud, M. Shelden, R. Soules, M. Valbuena, D. Wang, C. Wilcox, L. Yu, S. Yudin, M. Twin Research , 4 , 4 — Zweig, M. Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. Sign In or Create an Account. Sign In. Advanced Search. Search Menu. Article Navigation.
Close mobile search navigation Article Navigation. Volume Article Contents Abstract. Materials and methods. Risk factors for high-order multiple implantation after ovarian stimulation with gonadotrophins: evidence from a large series of consecutive pregnancies in a single centre. Rosa Tur , Rosa Tur. Oxford Academic. Google Scholar. Pedro N. Buenaventura Coroleu. Rosario Buxaderas. Juan Balasch. Select Format Select format.
Permissions Icon Permissions. Table I. Patient characteristics Age years Open in new tab. Table II. CDC Issue Section:. Download all slides. View Metrics. Email alerts Article activity alert. Advance article alerts. New issue alert. Receive exclusive offers and updates from Oxford Academic. More on this topic Treatment of anovulatory infertility: the problem of multiple pregnancy. Perifollicular vascularity in poor ovarian responders during IVF. Related articles in Web of Science Google Scholar.
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